Volak, Laurie P

Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Aug 2008 - 1594-605 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1521-009X

10.1124/dmd.108.020552 doi


Acetaminophen--metabolism
Alkaloids--pharmacology
Benzodioxoles--pharmacology
Chromatography, High Pressure Liquid
Curcumin--pharmacology
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors--pharmacology
Glucuronosyltransferase--antagonists & inhibitors
Humans
Liver--drug effects
Piperidines--pharmacology
Polyunsaturated Alkamides--pharmacology
Recombinant Proteins--antagonists & inhibitors
Spectrometry, Fluorescence
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Ultraviolet
Sulfotransferases--antagonists & inhibitors