TY  - GEN
AU  - Cumming,J N
AU  - Le,T X
AU  - Babu,S
AU  - Carroll,C
AU  - Chen,X
AU  - Favreau,L
AU  - Gaspari,P
AU  - Guo,T
AU  - Hobbs,D W
AU  - Huang,Y
AU  - Iserloh,U
AU  - Kennedy,M E
AU  - Kuvelkar,R
AU  - Li,G
AU  - Lowrie,J
AU  - McHugh,N A
AU  - Ozgur,L
AU  - Pan,J
AU  - Parker,E M
AU  - Saionz,K
AU  - Stamford,A W
AU  - Strickland,C
AU  - Tadesse,D
AU  - Voigt,J
AU  - Wang,L
AU  - Wu,Y
AU  - Zhang,L
AU  - Zhang,Q
TI  - Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors
SN  - 1464-3405
PY  - 2008///0709
KW  - Amyloid Precursor Protein Secretases
KW  - antagonists & inhibitors
KW  - Animals
KW  - Aspartic Acid Endopeptidases
KW  - Crystallography, X-Ray
KW  - Disease Models, Animal
KW  - Drug Design
KW  - Humans
KW  - Imidazolidines
KW  - chemical synthesis
KW  - Mice
KW  - Mice, Transgenic
KW  - Models, Molecular
KW  - Molecular Conformation
KW  - Molecular Structure
KW  - Piperazines
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1016/j.bmcl.2008.04.050
ER  -