Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo. [electronic resource]
- Experimental biology and medicine (Maywood, N.J.) Jul 2008
- 881-90 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1535-3702
10.3181/0712-RM-329 doi
Acetylcysteine--adverse effects Animals Cysteine Proteinase Inhibitors--adverse effects Disease Models, Animal Dopamine--metabolism Glial Cell Line-Derived Neurotrophic Factor--therapeutic use JNK Mitogen-Activated Protein Kinases--metabolism Male Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase Kinases--metabolism Nerve Degeneration--metabolism Parkinson Disease--etiology Phosphatidylinositol 3-Kinases--metabolism Proteasome Inhibitors Proto-Oncogene Proteins c-akt--metabolism Random Allocation Signal Transduction--drug effects Substantia Nigra--drug effects p38 Mitogen-Activated Protein Kinases--metabolism