TY  - GEN
AU  - Zhou,C
AU  - Wu,G
AU  - Feng,Y
AU  - Li,Q
AU  - Su,H
AU  - Mais,D E
AU  - Zhu,Y
AU  - Li,N
AU  - Deng,Y
AU  - Yang,D
AU  - Wang,M-W
TI  - Discovery and biological characterization of a novel series of androgen receptor modulators
SN  - 0007-1188
PY  - 2008///0619
KW  - Androgen Antagonists
KW  - chemistry
KW  - Androgen Receptor Antagonists
KW  - Anilides
KW  - pharmacology
KW  - Animals
KW  - Antineoplastic Agents, Hormonal
KW  - Binding, Competitive
KW  - Cell Line
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Dose-Response Relationship, Drug
KW  - Drug Design
KW  - Genes, Reporter
KW  - Humans
KW  - Male
KW  - Mice
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Nitriles
KW  - Orchiectomy
KW  - Pilot Projects
KW  - Prostate
KW  - Prostatic Neoplasms
KW  - drug therapy
KW  - Protein Binding
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Receptors, Androgen
KW  - genetics
KW  - Reproducibility of Results
KW  - Seminal Vesicles
KW  - Small Molecule Libraries
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Testosterone
KW  - metabolism
KW  - Tosyl Compounds
KW  - Transcriptional Activation
KW  - Transfection
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/bjp.2008.107
ER  -