Discovery and biological characterization of a novel series of androgen receptor modulators. [electronic resource]
- British journal of pharmacology May 2008
- 440-50 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0007-1188
10.1038/bjp.2008.107 doi
Androgen Antagonists--chemistry Androgen Receptor Antagonists Anilides--pharmacology Animals Antineoplastic Agents, Hormonal--chemistry Binding, Competitive Cell Line Cell Line, Tumor Cell Proliferation--drug effects Dose-Response Relationship, Drug Drug Design Genes, Reporter Humans Male Mice Models, Molecular Molecular Structure Nitriles--pharmacology Orchiectomy Pilot Projects Prostate--drug effects Prostatic Neoplasms--drug therapy Protein Binding Rats Rats, Sprague-Dawley Receptors, Androgen--genetics Reproducibility of Results Seminal Vesicles--drug effects Small Molecule Libraries Stereoisomerism Structure-Activity Relationship Testosterone--metabolism Tosyl Compounds--pharmacology Transcriptional Activation--drug effects Transfection