Native, amyloid fibrils and beta-oligomers of the C-terminal domain of human prion protein display differential activation of complement and bind C1q, factor H and C4b-binding protein directly. [electronic resource]
- Molecular immunology Jun 2008
- 3213-21 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0161-5890
10.1016/j.molimm.2008.02.023 doi
Amyloid--chemistry Complement Activation--drug effects Complement C1q--chemistry Complement C4b-Binding Protein--immunology Complement Factor H--immunology Complement Pathway, Alternative--drug effects Copper--pharmacology Humans Mutant Proteins--chemistry PrPC Proteins--chemistry Protein Binding--drug effects Protein Isoforms--chemistry Protein Structure, Quaternary Protein Structure, Tertiary