TY  - GEN
AU  - Ruel,Réjean
AU  - Thibeault,Carl
AU  - L'Heureux,Alexandre
AU  - Martel,Alain
AU  - Cai,Zhen-Wei
AU  - Wei,Donna
AU  - Qian,Ligang
AU  - Barrish,Joel C
AU  - Mathur,Arvind
AU  - D'Arienzo,Celia
AU  - Hunt,John T
AU  - Kamath,Amrita
AU  - Marathe,Punit
AU  - Zhang,Yueping
AU  - Derbin,George
AU  - Wautlet,Barri
AU  - Mortillo,Steven
AU  - Jeyaseelan,Robert
AU  - Henley,Benjamin
AU  - Tejwani,Ravindra
AU  - Bhide,Rajeev S
AU  - Trainor,George L
AU  - Fargnoli,Joseph
AU  - Lombardo,Louis J
TI  - Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor
SN  - 1464-3405
PY  - 2008///0715
KW  - Angiogenesis Inhibitors
KW  - chemical synthesis
KW  - Animals
KW  - Cell Line
KW  - Cytochrome P-450 CYP3A Inhibitors
KW  - Drug Design
KW  - ERG1 Potassium Channel
KW  - Ether-A-Go-Go Potassium Channels
KW  - antagonists & inhibitors
KW  - Humans
KW  - Inhibitory Concentration 50
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Protein-Tyrosine Kinases
KW  - Pyrroles
KW  - Structure-Activity Relationship
KW  - Triazines
KW  - Vascular Endothelial Growth Factor Receptor-2
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.bmcl.2008.03.057
ER  -