Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity for the dopamine and serotonin transporters. [electronic resource]
- Journal of medicinal chemistry May 2008
- 2795-806 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
0022-2623
10.1021/jm701270n doi
Dopamine Plasma Membrane Transport Proteins--metabolism Piperazines--chemical synthesis Radioligand Assay Serotonin Plasma Membrane Transport Proteins--metabolism Stereoisomerism Structure-Activity Relationship