Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells. [electronic resource]
- Journal of cellular physiology Sep 2008
- 698-707 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1097-4652
10.1002/jcp.21444 doi
Animals Antibodies, Monoclonal--pharmacology Antibodies, Monoclonal, Humanized Antineoplastic Agents--pharmacology Apoptosis--drug effects Boronic Acids--pharmacology Bortezomib Cell Line, Tumor--drug effects Cetuximab Dose-Response Relationship, Drug Drug Combinations Drug Synergism Enzyme Activation ErbB Receptors--antagonists & inhibitors Gefitinib Humans Mitogen-Activated Protein Kinases--genetics Piperidines--pharmacology Proteasome Endopeptidase Complex--metabolism Proteasome Inhibitors Proto-Oncogene Proteins c-akt--genetics Pyrazines--pharmacology Quinazolines--pharmacology Signal Transduction--physiology