Eddine, Ali Nasser <br/><br/>
X-ray structure of 4,4'-dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14alpha-demethylase (CYP51).  [electronic resource] 

 -  The Journal of biological chemistry  May 2008 
 - 15152-9 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. 
<br/><br/><label>ISSN: </label>0021-9258 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M801145200  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Bacterial Proteins--antagonists & inhibitors<br/>Benzophenones--chemistry<br/>Binding Sites--drug effects<br/>Cell Membrane--metabolism<br/>Cells, Cultured<br/>Crystallography, X-Ray<br/>Cytochrome P-450 Enzyme Inhibitors<br/>Cytochrome P-450 Enzyme System--chemistry<br/>Humans<br/>Macrophages--metabolism<br/>Mice<br/>Models, Molecular<br/>Mycobacterium tuberculosis--enzymology<br/>Mycoses--drug therapy<br/>Protein Structure, Tertiary<br/>Sterols--biosynthesis<br/>Structural Homology, Protein<br/>Tuberculosis--drug therapy