TY - GEN AU - Hengstler,J G AU - Bolt,H M TI - Loss of DNA damage checkpoint genes: switch from preferential induction of point mutations to chromosomal damage precedes the transition towards an aggressive cancer type SN - 0340-5761 PY - 2008///0819 KW - Aneuploidy KW - Cell Cycle KW - genetics KW - Cell Transformation, Neoplastic KW - Chromosomal Instability KW - DNA Damage KW - Gene Expression Regulation, Neoplastic KW - Genes, cdc KW - physiology KW - Humans KW - Mutagenesis KW - Point Mutation KW - Urinary Bladder Neoplasms N1 - Publication Type: Comment; Editorial UR - https://doi.org/10.1007/s00204-008-0295-9 ER -