Huang, Jing SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts. [electronic resource] - PloS one Mar 2008 - e1710 p. digital Publication Type: Journal Article; Research Support, Non-U.S. Gov't ISSN: 1932-6203 Standard No.: 10.1371/journal.pone.0001710 doi Subjects--Topical Terms: Antibiotics, Antineoplastic--pharmacologyBlotting, WesternCell Cycle--physiologyCell ProliferationCells, CulturedCellular Senescence--physiologyCyclin-Dependent Kinase Inhibitor p16--metabolismDiploidyExtracellular Signal-Regulated MAP Kinases--metabolismFibroblasts--metabolismHumansPhosphorylationRetinoblastoma Protein--metabolismRibosomal Protein S6 Kinases--metabolismSignal TransductionSirolimus--pharmacologySirtuin 1Sirtuins--antagonists & inhibitorsbeta-Galactosidase--metabolism