TY  - GEN
AU  - Hartnett,John C
AU  - Barnett,Stanley F
AU  - Bilodeau,Mark T
AU  - Defeo-Jones,Deborah
AU  - Hartman,George D
AU  - Huber,Hans E
AU  - Jones,Raymond E
AU  - Kral,Astrid M
AU  - Robinson,Ronald G
AU  - Wu,Zhicai
TI  - Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors
SN  - 1464-3405
PY  - 2008///0609
KW  - Allosteric Site
KW  - Animals
KW  - Apoptosis
KW  - drug effects
KW  - Caspases
KW  - metabolism
KW  - Dogs
KW  - Humans
KW  - Male
KW  - Metabolic Clearance Rate
KW  - Molecular Structure
KW  - Prostatic Neoplasms
KW  - drug therapy
KW  - Protein Kinase Inhibitors
KW  - chemical synthesis
KW  - Proto-Oncogene Proteins c-akt
KW  - antagonists & inhibitors
KW  - Pyridines
KW  - chemistry
KW  - Structure-Activity Relationship
KW  - TNF-Related Apoptosis-Inducing Ligand
KW  - pharmacology
KW  - Tumor Cells, Cultured
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.bmcl.2007.12.040
ER  -