TY  - GEN
AU  - Ott,Gregory R
AU  - Asakawa,Naoyuki
AU  - Liu,Rui-Qin
AU  - Covington,Maryanne B
AU  - Qian,Mingxin
AU  - Vaddi,Krishna
AU  - Newton,Robert C
AU  - Trzaskos,James M
AU  - Christ,David D
AU  - Galya,Laurine
AU  - Scholz,Thomas
AU  - Marshall,Will
AU  - Duan,James J-W
TI  - Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
SN  - 1464-3405
PY  - 2008///0512
KW  - ADAM Proteins
KW  - antagonists & inhibitors
KW  - ADAM17 Protein
KW  - Administration, Oral
KW  - Alkanes
KW  - chemical synthesis
KW  - Animals
KW  - Biological Availability
KW  - Caco-2 Cells
KW  - Humans
KW  - Hydroxamic Acids
KW  - Matrix Metalloproteinase Inhibitors
KW  - Matrix Metalloproteinases
KW  - metabolism
KW  - Models, Molecular
KW  - Protease Inhibitors
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Spiro Compounds
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.bmcl.2008.01.030
ER  -