Zhou, Yuefen <br/><br/>
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  Feb 2008 
 - 1419-24 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2008.01.005  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Crystallography, X-Ray<br/>Drug Design<br/>Drug Stability<br/>Enzyme Inhibitors--chemical synthesis<br/>Humans<br/>Inhibitory Concentration 50<br/>Microsomes, Liver--metabolism<br/>Models, Molecular<br/>Pyridazines--chemical synthesis<br/>RNA-Dependent RNA Polymerase--antagonists & inhibitors<br/>Thiadiazines--chemical synthesis<br/>Viral Nonstructural Proteins--antagonists & inhibitors