TY  - GEN
AU  - Thurmond,John
AU  - Butchbach,Matthew E R
AU  - Palomo,Marty
AU  - Pease,Brian
AU  - Rao,Munagala
AU  - Bedell,Louis
AU  - Keyvan,Monica
AU  - Pai,Grace
AU  - Mishra,Rama
AU  - Haraldsson,Magnus
AU  - Andresson,Thorkell
AU  - Bragason,Gisli
AU  - Thosteinsdottir,Margret
AU  - Bjornsson,Jon Mar
AU  - Coovert,Daniel D
AU  - Burghes,Arthur H M
AU  - Gurney,Mark E
AU  - Singh,Jasbir
TI  - Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy
SN  - 0022-2623
PY  - 2008///0505
KW  - Aminoquinolines
KW  - chemical synthesis
KW  - Animals
KW  - Biological Availability
KW  - Blood-Brain Barrier
KW  - metabolism
KW  - Cell Line
KW  - Cells, Cultured
KW  - Cyclic AMP Response Element-Binding Protein
KW  - genetics
KW  - Fibroblasts
KW  - drug effects
KW  - Folic Acid Antagonists
KW  - Heterozygote
KW  - Humans
KW  - Mice
KW  - Models, Molecular
KW  - Molecular Conformation
KW  - Muscular Atrophy, Spinal
KW  - drug therapy
KW  - Nerve Tissue Proteins
KW  - Permeability
KW  - Piperidines
KW  - Promoter Regions, Genetic
KW  - Quinazolines
KW  - RNA-Binding Proteins
KW  - SMN Complex Proteins
KW  - Spinal Muscular Atrophies of Childhood
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Survival of Motor Neuron 1 Protein
KW  - Survival of Motor Neuron 2 Protein
KW  - Tetrahydrofolate Dehydrogenase
KW  - chemistry
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/jm061475p
ER  -