Thurmond, John <br/><br/>
Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy.  [electronic resource] 

 -  Journal of medicinal chemistry  Feb 2008 
 - 449-69 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm061475p  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aminoquinolines--chemical synthesis<br/>Animals<br/>Biological Availability<br/>Blood-Brain Barrier--metabolism<br/>Cell Line<br/>Cells, Cultured<br/>Cyclic AMP Response Element-Binding Protein--genetics<br/>Fibroblasts--drug effects<br/>Folic Acid Antagonists--chemical synthesis<br/>Heterozygote<br/>Humans<br/>Mice<br/>Models, Molecular<br/>Molecular Conformation<br/>Muscular Atrophy, Spinal--drug therapy<br/>Nerve Tissue Proteins--genetics<br/>Permeability<br/>Piperidines--chemical synthesis<br/>Promoter Regions, Genetic<br/>Quinazolines--chemical synthesis<br/>RNA-Binding Proteins--genetics<br/>SMN Complex Proteins<br/>Spinal Muscular Atrophies of Childhood--genetics<br/>Stereoisomerism<br/>Structure-Activity Relationship<br/>Survival of Motor Neuron 1 Protein<br/>Survival of Motor Neuron 2 Protein<br/>Tetrahydrofolate Dehydrogenase--chemistry