SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. [electronic resource]
- Arteriosclerosis, thrombosis, and vascular biology Apr 2008
- 665-71 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1524-4636
10.1161/ATVBAHA.107.158030 doi
Activin Receptors, Type I--antagonists & inhibitors Adenosine Triphosphate--metabolism Administration, Oral Animals Azabicyclo Compounds--administration & dosage Binding Sites Carotid Artery Injuries--drug therapy Cell Line Fibroblasts--drug effects Fibrosis Humans Male Myoblasts, Smooth Muscle--drug effects Protein Kinase Inhibitors--administration & dosage Protein Serine-Threonine Kinases--antagonists & inhibitors Rats Rats, Sprague-Dawley Receptor, Transforming Growth Factor-beta Type I Receptors, Transforming Growth Factor beta--antagonists & inhibitors Transforming Growth Factor beta--physiology