Hook, Vivian Y H <br/><br/>
Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.  [electronic resource] 

 -  The Journal of biological chemistry  Mar 2008 
 - 7745-53 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural 
<br/><br/><label>ISSN: </label>0021-9258 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M708362200  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alzheimer Disease--drug therapy<br/>Amyloid Precursor Protein Secretases--antagonists & inhibitors<br/>Amyloid beta-Protein Precursor--genetics<br/>Animals<br/>Cathepsin B--genetics<br/>Cattle<br/>Cysteine Proteinase Inhibitors--pharmacology<br/>Dipeptides--pharmacology<br/>Disease Models, Animal<br/>Drug Evaluation, Preclinical<br/>Gene Expression<br/>Humans<br/>Leucine--analogs & derivatives<br/>Maze Learning--drug effects<br/>Memory--drug effects<br/>Mice<br/>Mice, Transgenic