TY - GEN AU - Gowda,Aruna AU - Roda,Julie AU - Hussain,Syed-Rehan A AU - Ramanunni,Asha AU - Joshi,Trupti AU - Schmidt,Susan AU - Zhang,Xiaoli AU - Lehman,Amy AU - Jarjoura,David AU - Carson,William E AU - Kindsvogel,Wayne AU - Cheney,Carolyn AU - Caligiuri,Michael A AU - Tridandapani,Susheela AU - Muthusamy,Natarajan AU - Byrd,John C TI - IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro SN - 1528-0020 PY - 2008///0716 KW - Antibodies, Monoclonal KW - pharmacology KW - Antibodies, Monoclonal, Murine-Derived KW - Antibody-Dependent Cell Cytotoxicity KW - Apoptosis KW - Apoptosis Regulatory Proteins KW - genetics KW - Bcl-2-Like Protein 11 KW - Cytotoxicity, Immunologic KW - Humans KW - Interleukins KW - physiology KW - Membrane Proteins KW - Proto-Oncogene Proteins KW - Rituximab KW - STAT1 Transcription Factor KW - metabolism KW - STAT5 Transcription Factor KW - Up-Regulation KW - Vidarabine KW - analogs & derivatives KW - Interleukin-21 N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1182/blood-2007-07-099531 ER -