TY  - GEN
AU  - Ghosh,Arun K
AU  - Kumaragurubaran,Nagaswamy
AU  - Hong,Lin
AU  - Kulkarni,Sarang
AU  - Xu,Xiaoming
AU  - Miller,Heather B
AU  - Reddy,Dandepally Srinivasa
AU  - Weerasena,Vajira
AU  - Turner,Robert
AU  - Chang,Wanpin
AU  - Koelsch,Gerald
AU  - Tang,Jordan
TI  - Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation
SN  - 1464-3405
PY  - 2008///0324
KW  - Alzheimer Disease
KW  - drug therapy
KW  - Amyloid Precursor Protein Secretases
KW  - antagonists & inhibitors
KW  - Animals
KW  - Aspartic Acid
KW  - analogs & derivatives
KW  - Aspartic Acid Endopeptidases
KW  - Cricetinae
KW  - Cricetulus
KW  - Crystallography, X-Ray
KW  - Dipeptides
KW  - chemical synthesis
KW  - Drug Design
KW  - Female
KW  - Humans
KW  - Mice
KW  - Mice, Transgenic
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Structure-Activity Relationship
KW  - Sulfonamides
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural
UR  - https://doi.org/10.1016/j.bmcl.2007.12.028
ER  -