Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma. [electronic resource]
- Blood Apr 2008
- 4173-83 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0006-4971
10.1182/blood-2007-01-068908 doi
Cholesterol--deficiency Enzyme Activation--drug effects Humans Immunoglobulin G--pharmacology Interferon-gamma--biosynthesis Interleukin-12--pharmacology Intracellular Signaling Peptides and Proteins--metabolism JNK Mitogen-Activated Protein Kinases--metabolism Killer Cells, Natural--cytology Membrane Microdomains--enzymology Mitogen-Activated Protein Kinase 3--antagonists & inhibitors Phosphatidylinositol 3-Kinases--metabolism Protein Kinase Inhibitors--pharmacology Protein Transport--drug effects Protein-Tyrosine Kinases--metabolism Proto-Oncogene Proteins c-akt--metabolism Receptors, IgG--immunology Receptors, Interleukin-12--immunology STAT4 Transcription Factor--metabolism Syk Kinase p38 Mitogen-Activated Protein Kinases--metabolism