Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation. [electronic resource]
- Journal of vascular surgery Dec 2007
- 1253-1259 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0741-5214
10.1016/j.jvs.2007.08.013 doi
Animals Cell Movement--drug effects Cells, Cultured Enzyme Activation Estrenes--pharmacology GTP-Binding Protein alpha Subunits, G12-G13--antagonists & inhibitors Lysophospholipids--metabolism MAP Kinase Signaling System Mitogen-Activated Protein Kinase 1--metabolism Mitogen-Activated Protein Kinase 3--metabolism Muscle, Smooth, Vascular--drug effects Myocytes, Smooth Muscle--drug effects NADPH Oxidases--antagonists & inhibitors Onium Compounds--pharmacology Pertussis Toxin--pharmacology Phosphodiesterase Inhibitors--pharmacology Phospholipase C beta--antagonists & inhibitors Phospholipase C gamma--metabolism Phosphorylation Pyrrolidinones--pharmacology RNA Interference RNA, Small Interfering--metabolism Rats Rats, Sprague-Dawley Reactive Oxygen Species--metabolism Signal Transduction--drug effects Sphingosine--analogs & derivatives Time Factors p38 Mitogen-Activated Protein Kinases--metabolism