TY - GEN AU - Yang,Xiang-Lei AU - Kapoor,Mili AU - Otero,Francella J AU - Slike,Bonnie M AU - Tsuruta,Hiro AU - Frausto,Ricardo AU - Bates,Alison AU - Ewalt,Karla L AU - Cheresh,David A AU - Schimmel,Paul TI - Gain-of-function mutational activation of human tRNA synthetase procytokine SN - 1074-5521 PY - 2008///0319 KW - Amino Acid Motifs KW - genetics KW - Amino Acid Substitution KW - Animals KW - Cattle KW - Cell Movement KW - drug effects KW - Cell Proliferation KW - Chemotaxis, Leukocyte KW - Chick Embryo KW - Cytokines KW - metabolism KW - Endothelial Cells KW - cytology KW - Humans KW - Leukocytes, Mononuclear KW - Mice KW - Mice, Nude KW - Models, Molecular KW - Mutation KW - Neovascularization, Physiologic KW - Peptide Fragments KW - chemistry KW - Peptide Hydrolases KW - Protein Conformation KW - Protein Structure, Tertiary KW - Scattering, Small Angle KW - Tyrosine-tRNA Ligase KW - X-Ray Diffraction N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S UR - https://doi.org/10.1016/j.chembiol.2007.10.016 ER -