TY - GEN AU - DeLuca,G C AU - Ramagopalan,S V AU - Herrera,B M AU - Dyment,D A AU - Lincoln,M R AU - Montpetit,A AU - Pugliatti,M AU - Barnardo,M C N AU - Risch,N J AU - Sadovnick,A D AU - Chao,M AU - Sotgiu,S AU - Hudson,T J AU - Ebers,G C TI - An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus SN - 1091-6490 PY - 2008///0115 KW - Adult KW - Alleles KW - Disease Progression KW - Female KW - Gene Expression Regulation KW - Gene Frequency KW - Genetic Predisposition to Disease KW - HLA-DR Antigens KW - genetics KW - HLA-DRB1 Chains KW - Humans KW - Italy KW - Male KW - Middle Aged KW - Models, Genetic KW - Multiple Sclerosis KW - diagnosis KW - Phenotype KW - Polymorphism, Single Nucleotide KW - Treatment Outcome N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1073/pnas.0707731105 ER -