An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America Dec 2007
- 20896-901 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.0707731105 doi
Adult Alleles Disease Progression Female Gene Expression Regulation Gene Frequency Genetic Predisposition to Disease HLA-DR Antigens--genetics HLA-DRB1 Chains Humans Italy Male Middle Aged Models, Genetic Multiple Sclerosis--diagnosis Phenotype Polymorphism, Single Nucleotide Treatment Outcome