Tsutsumi, R <br/><br/>
Celecoxib inhibits production of MMP and NO via down-regulation of NF-kappaB and JNK in a PGE2 independent manner in human articular chondrocytes.  [electronic resource] 

 -  Rheumatology international  Jun 2008 
 - 727-36 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0172-8172 
<br/><br/><label>Standard No.: </label>10.1007/s00296-007-0511-6  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aged<br/>Cartilage, Articular--cytology<br/>Celecoxib<br/>Cells, Cultured<br/>Chondrocytes--drug effects<br/>Cyclooxygenase 2--metabolism<br/>Cyclooxygenase Inhibitors--pharmacology<br/>Dinoprostone--pharmacology<br/>Down-Regulation--drug effects<br/>Enzyme Activation--drug effects<br/>Humans<br/>Interleukin-1beta--pharmacology<br/>JNK Mitogen-Activated Protein Kinases--metabolism<br/>Matrix Metalloproteinase 1--biosynthesis<br/>Matrix Metalloproteinase 3--biosynthesis<br/>Matrix Metalloproteinases--biosynthesis<br/>NF-kappa B--metabolism<br/>Nitric Oxide--biosynthesis<br/>Nitric Oxide Synthase Type II--metabolism<br/>Phosphorylation--drug effects<br/>Pyrazoles--pharmacology<br/>Sulfonamides--pharmacology