Orphan nuclear receptor estrogen-related receptor-beta suppresses in vitro and in vivo growth of prostate cancer cells via p21(WAF1/CIP1) induction and as a potential therapeutic target in prostate cancer. [electronic resource]
- Oncogene May 2008
- 3313-28 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5594
10.1038/sj.onc.1210986 doi
Animals Antineoplastic Agents--therapeutic use Carcinoma--drug therapy Cell Cycle--genetics Cell Proliferation--drug effects Cells, Cultured Cyclin-Dependent Kinase Inhibitor p21--genetics Drug Delivery Systems Gene Expression Regulation, Neoplastic HeLa Cells Heat-Shock Proteins--physiology Histone Deacetylases--metabolism Histones--metabolism Humans Male Mice Mice, SCID Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Prostatic Neoplasms--drug therapy Protein Structure, Tertiary--physiology Receptors, Estrogen--agonists Transcription Factors--physiology Transfection Transplantation, Heterologous Up-Regulation