TY  - GEN
AU  - Biggadike,Keith
AU  - Boudjelal,Mohamed
AU  - Clackers,Margaret
AU  - Coe,Diane M
AU  - Demaine,Derek A
AU  - Hardy,George W
AU  - Humphreys,Davina
AU  - Inglis,Graham G A
AU  - Johnston,Michael J
AU  - Jones,Haydn T
AU  - House,David
AU  - Loiseau,Richard
AU  - Needham,Deborah
AU  - Skone,Philip A
AU  - Uings,Iain
AU  - Veitch,Gemma
AU  - Weingarten,Gordon G
AU  - McLay,Iain M
AU  - Macdonald,Simon J F
TI  - Nonsteroidal glucocorticoid agonists: tetrahydronaphthalenes with alternative steroidal A-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivity
SN  - 0022-2623
PY  - 2008///0403
KW  - Anti-Inflammatory Agents, Non-Steroidal
KW  - chemical synthesis
KW  - Binding Sites
KW  - Cell Line
KW  - Drug Partial Agonism
KW  - Humans
KW  - Mammary Tumor Virus, Mouse
KW  - genetics
KW  - Models, Molecular
KW  - Molecular Mimicry
KW  - NF-kappa B
KW  - Receptors, Glucocorticoid
KW  - agonists
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Tetrahydronaphthalenes
KW  - Transcription, Genetic
KW  - drug effects
KW  - Transcriptional Activation
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm070778w
ER  -