TY - GEN AU - Herlands,Robin A AU - William,Jacqueline AU - Hershberg,Uri AU - Shlomchik,Mark J TI - Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites SN - 0014-2980 PY - 2008///0228 KW - Animals KW - Antibodies, Antinuclear KW - immunology KW - Autoimmunity KW - genetics KW - B-Lymphocyte Subsets KW - Chromatin KW - Disease Models, Animal KW - Genetic Predisposition to Disease KW - Immunoglobulin G KW - Lupus Erythematosus, Systemic KW - Lymphocyte Activation KW - Lymphocyte Cooperation KW - Mice KW - Mice, Inbred BALB C KW - Mice, Inbred MRL lpr KW - Mice, Transgenic KW - Nucleosomes KW - Organ Specificity KW - Particle Size KW - Rheumatoid Factor KW - Somatic Hypermutation, Immunoglobulin KW - Specific Pathogen-Free Organisms KW - Spleen KW - Toll-Like Receptors N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1002/eji.200737752 ER -