Heteroaryl-substituted 4-(1H-pyrazol-1-yl)-5,6-dihydro-1H-pyrrolo[2,3-d]pyrimidine derivatives as potent and selective corticotropin-releasing factor receptor-1 antagonists. [electronic resource]
- ChemMedChem Feb 2008
- 226-9 p. digital
Publication Type: Journal Article
1860-7187
10.1002/cmdc.200700230 doi
Animals Anxiety--drug therapy Corticotropin-Releasing Hormone--metabolism Depression--drug therapy Drug Design Models, Chemical Pyrazoles--chemical synthesis Pyrimidines--chemical synthesis Rats Rats, Wistar Receptors, Corticotropin-Releasing Hormone--antagonists & inhibitors Structure-Activity Relationship CRF Receptor, Type 1