TY - GEN AU - Bai,Xiaochun AU - Ma,Dongzhu AU - Liu,Anling AU - Shen,Xiaoyun AU - Wang,Qiming J AU - Liu,Yongjian AU - Jiang,Yu TI - Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38 SN - 1095-9203 PY - 2007///1123 KW - Amino Acids KW - metabolism KW - Cell Line KW - Culture Media KW - Guanosine Triphosphate KW - Humans KW - Insulin KW - Intercellular Signaling Peptides and Proteins KW - Mechanistic Target of Rapamycin Complex 1 KW - Monomeric GTP-Binding Proteins KW - Multiprotein Complexes KW - Mutant Proteins KW - Neuropeptides KW - Phosphorylation KW - Protein Binding KW - Protein Kinases KW - chemistry KW - Protein Structure, Tertiary KW - Proteins KW - Ras Homolog Enriched in Brain Protein KW - Recombinant Proteins KW - Serum KW - Signal Transduction KW - Sirolimus KW - TOR Serine-Threonine Kinases KW - Tacrolimus Binding Proteins KW - antagonists & inhibitors KW - Transcription Factors N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S UR - https://doi.org/10.1126/science.1147379 ER -