TY  - GEN
AU  - Toral-Barza,Lourdes
AU  - Zhang,Wei-Guo
AU  - Huang,Xinyi
AU  - McDonald,Leonard A
AU  - Salaski,Edward J
AU  - Barbieri,Laurel R
AU  - Ding,Wei-Dong
AU  - Krishnamurthy,Girija
AU  - Hu,Yong Bo
AU  - Lucas,Judy
AU  - Bernan,Valerie S
AU  - Cai,Ping
AU  - Levin,Jeremy I
AU  - Mansour,Tarek S
AU  - Gibbons,James J
AU  - Abraham,Robert T
AU  - Yu,Ker
TI  - Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines
SN  - 1535-7163
PY  - 2008///0215
KW  - Adenosine Triphosphate
KW  - pharmacology
KW  - Allosteric Regulation
KW  - drug effects
KW  - Animals
KW  - Catalysis
KW  - Cell Line, Tumor
KW  - Cysteine
KW  - metabolism
KW  - Down-Regulation
KW  - Enzyme Activation
KW  - Enzyme Inhibitors
KW  - chemistry
KW  - Humans
KW  - Kinetics
KW  - Naphthoquinones
KW  - Phosphorylation
KW  - Protein Biosynthesis
KW  - Protein Kinases
KW  - Proto-Oncogene Proteins c-akt
KW  - antagonists & inhibitors
KW  - RNA Caps
KW  - Rats
KW  - Structure-Activity Relationship
KW  - Substrate Specificity
KW  - TOR Serine-Threonine Kinases
KW  - Time Factors
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1158/1535-7163.MCT-07-0211
ER  -