Toral-Barza, Lourdes <br/><br/>
Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines.  [electronic resource] 

 -  Molecular cancer therapeutics  Nov 2007 
 - 3028-38 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1535-7163 
<br/><br/><label>Standard No.: </label>10.1158/1535-7163.MCT-07-0211  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adenosine Triphosphate--pharmacology<br/>Allosteric Regulation--drug effects<br/>Animals<br/>Catalysis--drug effects<br/>Cell Line, Tumor<br/>Cysteine--metabolism<br/>Down-Regulation--drug effects<br/>Enzyme Activation--drug effects<br/>Enzyme Inhibitors--chemistry<br/>Humans<br/>Kinetics<br/>Naphthoquinones--chemistry<br/>Phosphorylation--drug effects<br/>Protein Biosynthesis--drug effects<br/>Protein Kinases--metabolism<br/>Proto-Oncogene Proteins c-akt--antagonists & inhibitors<br/>RNA Caps--metabolism<br/>Rats<br/>Structure-Activity Relationship<br/>Substrate Specificity--drug effects<br/>TOR Serine-Threonine Kinases<br/>Time Factors