TY  - GEN
AU  - Nishioka,Chie
AU  - Ikezoe,Takayuki
AU  - Yang,Jing
AU  - Takeshita,Ayako
AU  - Taniguchi,Ayuko
AU  - Komatsu,Naoki
AU  - Togitani,Kazuto
AU  - Koeffler,H Phillip
AU  - Yokoyama,Akihito
TI  - Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene
SN  - 0145-2126
PY  - 2008///0522
KW  - Aged
KW  - Aged, 80 and over
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - Apoptosis
KW  - drug effects
KW  - Benzimidazoles
KW  - therapeutic use
KW  - Cell Proliferation
KW  - Female
KW  - Humans
KW  - Indoles
KW  - Leukemia
KW  - drug therapy
KW  - Leukemia, Megakaryoblastic, Acute
KW  - Leukemia, Myeloid, Acute
KW  - MAP Kinase Kinase 1
KW  - antagonists & inhibitors
KW  - Male
KW  - Middle Aged
KW  - Mitogen-Activated Protein Kinase 1
KW  - Mitogen-Activated Protein Kinase 3
KW  - Mutation
KW  - genetics
KW  - Pyrroles
KW  - Ribosomal Protein S6 Kinases, 70-kDa
KW  - Signal Transduction
KW  - Sunitinib
KW  - Tumor Cells, Cultured
KW  - fms-Like Tyrosine Kinase 3
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.leukres.2007.09.017
ER  -