Nishioka, Chie <br/><br/>
Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene.  [electronic resource] 

 -  Leukemia research  Jun 2008 
 - 865-72 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0145-2126 
<br/><br/><label>Standard No.: </label>10.1016/j.leukres.2007.09.017  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aged<br/>Aged, 80 and over<br/>Antineoplastic Combined Chemotherapy Protocols<br/>Apoptosis--drug effects<br/>Benzimidazoles--therapeutic use<br/>Cell Proliferation--drug effects<br/>Female<br/>Humans<br/>Indoles--therapeutic use<br/>Leukemia--drug therapy<br/>Leukemia, Megakaryoblastic, Acute--drug therapy<br/>Leukemia, Myeloid, Acute--drug therapy<br/>MAP Kinase Kinase 1--antagonists & inhibitors<br/>Male<br/>Middle Aged<br/>Mitogen-Activated Protein Kinase 1--antagonists & inhibitors<br/>Mitogen-Activated Protein Kinase 3--antagonists & inhibitors<br/>Mutation--genetics<br/>Pyrroles--therapeutic use<br/>Ribosomal Protein S6 Kinases, 70-kDa--antagonists & inhibitors<br/>Signal Transduction--drug effects<br/>Sunitinib<br/>Tumor Cells, Cultured<br/>fms-Like Tyrosine Kinase 3--genetics