Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone. [electronic resource]
- Bioorganic & medicinal chemistry Feb 2008
- 1309-18 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1464-3391
10.1016/j.bmc.2007.10.064 doi
Binding, Competitive Circular Dichroism Databases, Protein Drug Design Hydroxymethylglutaryl CoA Reductases--chemistry Hydroxymethylglutaryl-CoA Reductase Inhibitors--chemical synthesis Models, Biological Models, Molecular Peptides--chemical synthesis Protein Binding Protein Denaturation Protein Folding Protein Structure, Tertiary Structure-Activity Relationship Temperature