TY  - GEN
AU  - Hemnes,Anna R
AU  - Zaiman,Ari
AU  - Champion,Hunter C
TI  - PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation
SN  - 1040-0605
PY  - 2008///0410
KW  - Animals
KW  - Bleomycin
KW  - adverse effects
KW  - Cyclic Nucleotide Phosphodiesterases, Type 5
KW  - Enzyme Activation
KW  - Hypertension, Pulmonary
KW  - pathology
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Phosphodiesterase 5 Inhibitors
KW  - Phosphodiesterase Inhibitors
KW  - therapeutic use
KW  - Piperazines
KW  - Pulmonary Fibrosis
KW  - chemically induced
KW  - Purines
KW  - Reactive Oxygen Species
KW  - metabolism
KW  - Sildenafil Citrate
KW  - Sulfones
KW  - Ventricular Dysfunction, Right
KW  - rho-Associated Kinases
KW  - rhoA GTP-Binding Protein
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1152/ajplung.00245.2007
ER  -