Hemnes, Anna R <br/><br/>
PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation.  [electronic resource] 

 -  American journal of physiology. Lung cellular and molecular physiology  Jan 2008 
 - L24-33 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1040-0605 
<br/><br/><label>Standard No.: </label>10.1152/ajplung.00245.2007  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Bleomycin--adverse effects<br/>Cyclic Nucleotide Phosphodiesterases, Type 5<br/>Enzyme Activation<br/>Hypertension, Pulmonary--pathology<br/>Male<br/>Mice<br/>Mice, Inbred C57BL<br/>Phosphodiesterase 5 Inhibitors<br/>Phosphodiesterase Inhibitors--therapeutic use<br/>Piperazines--therapeutic use<br/>Pulmonary Fibrosis--chemically induced<br/>Purines--therapeutic use<br/>Reactive Oxygen Species--metabolism<br/>Sildenafil Citrate<br/>Sulfones--therapeutic use<br/>Ventricular Dysfunction, Right--chemically induced<br/>rho-Associated Kinases--metabolism<br/>rhoA GTP-Binding Protein--metabolism