TY  - GEN
AU  - Furber,Mark
AU  - Alcaraz,Lilian
AU  - Bent,Janice E
AU  - Beyerbach,Armin
AU  - Bowers,Keith
AU  - Braddock,Martin
AU  - Caffrey,Moya V
AU  - Cladingboel,David
AU  - Collington,John
AU  - Donald,David K
AU  - Fagura,Malbinder
AU  - Ince,Frank
AU  - Kinchin,Elizabeth C
AU  - Laurent,Celine
AU  - Lawson,Mandy
AU  - Luker,Timothy J
AU  - Mortimore,Michael M P
AU  - Pimm,Austen D
AU  - Riley,Robert J
AU  - Roberts,Nicola
AU  - Robertson,Mark
AU  - Theaker,Jill
AU  - Thorne,Philip V
AU  - Weaver,Richard
AU  - Webborn,Peter
AU  - Willis,Paul
TI  - Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors
SN  - 0022-2623
PY  - 2008///0227
KW  - Adamantane
KW  - analogs & derivatives
KW  - Animals
KW  - Benzamides
KW  - chemical synthesis
KW  - Blood Proteins
KW  - metabolism
KW  - Crystallography, X-Ray
KW  - Humans
KW  - In Vitro Techniques
KW  - Interleukin-1beta
KW  - antagonists & inhibitors
KW  - Molecular Conformation
KW  - Monocytes
KW  - Protein Binding
KW  - Purinergic P2 Receptor Antagonists
KW  - Rats
KW  - Receptors, Purinergic P2X7
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm700949w
ER  -