TY - GEN AU - Krzeski,Piotr AU - Buckland-Wright,Chris AU - Bálint,Géza AU - Cline,Gary A AU - Stoner,Karen AU - Lyon,Robert AU - Beary,John AU - Aronstein,William S AU - Spector,Tim D TI - Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study SN - 1478-6362 PY - 2008///0408 KW - Adult KW - Aged KW - Aged, 80 and over KW - Double-Blind Method KW - Female KW - Follow-Up Studies KW - Humans KW - Hydroxamic Acids KW - administration & dosage KW - Male KW - Matrix Metalloproteinase Inhibitors KW - Matrix Metalloproteinases KW - metabolism KW - Middle Aged KW - Musculoskeletal Diseases KW - chemically induced KW - Osteoarthritis, Knee KW - drug therapy KW - Protease Inhibitors N1 - Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1186/ar2315 ER -