DiFiglia, M <br/><br/>
Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.  [electronic resource] 

 -  Proceedings of the National Academy of Sciences of the United States of America  Oct 2007 
 - 17204-9 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0027-8424 
<br/><br/><label>Standard No.: </label>10.1073/pnas.0708285104  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Behavior, Animal--drug effects<br/>Cerebral Cortex--drug effects<br/>Cholesterol--metabolism<br/>Dependovirus<br/>Disease Models, Animal<br/>Gene Silencing<br/>Genetic Therapy<br/>Humans<br/>Huntingtin Protein<br/>Huntington Disease--pathology<br/>Injections<br/>Intranuclear Inclusion Bodies--drug effects<br/>Mice<br/>Motor Neuron Disease--pathology<br/>Mutant Proteins--antagonists & inhibitors<br/>Neostriatum--drug effects<br/>Nerve Tissue Proteins--antagonists & inhibitors<br/>Neurons--pathology<br/>Neuropil Threads--drug effects<br/>Nuclear Proteins--antagonists & inhibitors<br/>RNA, Small Interfering--pharmacology