Tao, Zhi-Fu <br/><br/>
Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  Dec 2007 
 - 6593-601 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2007.09.063  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Catalysis<br/>Checkpoint Kinase 1<br/>HeLa Cells<br/>Humans<br/>Macrocyclic Compounds--chemical synthesis<br/>Mice<br/>Protein Kinase Inhibitors--chemical synthesis<br/>Protein Kinases--pharmacokinetics<br/>Structure-Activity Relationship<br/>Urea--chemical synthesis