TY - GEN AU - Jantzen,F AU - Könemann,S AU - Wolff,B AU - Barth,S AU - Staudt,A AU - Kroemer,H-K AU - Dahm,J B AU - Felix,S B AU - Landsberger,M TI - Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells SN - 0867-5910 PY - 2007///1221 KW - Cell Survival KW - drug effects KW - Cells, Cultured KW - Dose-Response Relationship, Drug KW - Down-Regulation KW - Endothelium, Vascular KW - cytology KW - Fluorobenzenes KW - pharmacology KW - Humans KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Immunoblotting KW - Mevalonic Acid KW - Nitric Oxide KW - metabolism KW - Nitric Oxide Synthase Type II KW - genetics KW - Nitric Oxide Synthase Type III KW - Polyisoprenyl Phosphates KW - Pyridines KW - Pyrimidines KW - RNA, Messenger KW - Reverse Transcriptase Polymerase Chain Reaction KW - Rosuvastatin Calcium KW - Sesquiterpenes KW - Sulfonamides KW - Terpenes KW - Time Factors KW - Tumor Necrosis Factor-alpha KW - Umbilical Veins KW - Up-Regulation N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't ER -