Spink, David C

Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. [electronic resource] - Toxicology and applied pharmacology Feb 2008 - 213-24 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

0041-008X

10.1016/j.taap.2007.08.024 doi


Aryl Hydrocarbon Hydroxylases
Benzo(a)pyrene--metabolism
Biotransformation--drug effects
Breast Neoplasms--drug therapy
Cell Line, Tumor
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP1A1--biosynthesis
Cytochrome P-450 CYP1B1
Cytochrome P-450 Enzyme System--biosynthesis
Dose-Response Relationship, Drug
Drug Combinations
Enzyme Induction--drug effects
Female
Fluorenes--metabolism
Gas Chromatography-Mass Spectrometry
Humans
Microsomes, Liver--drug effects