Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. [electronic resource]
- Toxicology and applied pharmacology Feb 2008
- 213-24 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
0041-008X
10.1016/j.taap.2007.08.024 doi
Aryl Hydrocarbon Hydroxylases Benzo(a)pyrene--metabolism Biotransformation--drug effects Breast Neoplasms--drug therapy Cell Line, Tumor Chromatography, High Pressure Liquid Cytochrome P-450 CYP1A1--biosynthesis Cytochrome P-450 CYP1B1 Cytochrome P-450 Enzyme System--biosynthesis Dose-Response Relationship, Drug Drug Combinations Enzyme Induction--drug effects Female Fluorenes--metabolism Gas Chromatography-Mass Spectrometry Humans Microsomes, Liver--drug effects