TY - GEN AU - Ito,Shingo AU - Ohtsuki,Sumio AU - Kamiie,Junichi AU - Nezu,Yasuko AU - Terasaki,Tetsuya TI - Cerebral clearance of human amyloid-beta peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes SN - 1471-4159 PY - 2008///0108 KW - Alzheimer Disease KW - metabolism KW - Amyloid beta-Peptides KW - Animals KW - Apolipoproteins E KW - Blood-Brain Barrier KW - drug effects KW - Cell Line KW - Cerebral Cortex KW - Dimerization KW - Endocytosis KW - physiology KW - Humans KW - Lactoferrin KW - Ligands KW - Low Density Lipoprotein Receptor-Related Protein-1 KW - Macromolecular Substances KW - Male KW - Metabolic Clearance Rate KW - Mice KW - Peptide Fragments KW - Protein Binding KW - Rats KW - Rats, Sprague-Dawley KW - alpha-Macroglobulins N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1111/j.1471-4159.2007.04938.x ER -