TY  - GEN
AU  - Doshi,Jignesh M
AU  - Tian,Defeng
AU  - Xing,Chengguo
TI  - Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis
SN  - 1543-8384
PY  - 2008///0212
KW  - Animals
KW  - Apoptosis
KW  - drug effects
KW  - Benzopyrans
KW  - chemistry
KW  - Culture Media, Serum-Free
KW  - pharmacology
KW  - Humans
KW  - Nitriles
KW  - Proto-Oncogene Proteins c-bcl-2
KW  - antagonists & inhibitors
KW  - Reactive Oxygen Species
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/mp7000846
ER  -