Doshi, Jignesh M <br/><br/>
Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis.  [electronic resource] 

 -  Molecular pharmaceutics   
 - 919-28 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1543-8384 
<br/><br/><label>Standard No.: </label>10.1021/mp7000846  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Apoptosis--drug effects<br/>Benzopyrans--chemistry<br/>Culture Media, Serum-Free--pharmacology<br/>Humans<br/>Nitriles--chemistry<br/>Proto-Oncogene Proteins c-bcl-2--antagonists & inhibitors<br/>Reactive Oxygen Species--chemistry