Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. [electronic resource]
- Drug metabolism and disposition: the biological fate of chemicals Dec 2007
- 2166-76 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0090-9556
10.1124/dmd.107.017459 doi
ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters--metabolism Adenosine Triphosphate--metabolism Angiotensin II Type 1 Receptor Blockers--metabolism Animals Cell Line Dogs Dose-Response Relationship, Drug Estrone--analogs & derivatives Female Hepatocytes--drug effects Humans Imidazoles--metabolism In Vitro Techniques Kidney--metabolism Kinetics Liver--drug effects Liver-Specific Organic Anion Transporter 1 Membrane Transport Proteins--drug effects Mice Mice, Knockout Multidrug Resistance-Associated Protein 2 Multidrug Resistance-Associated Proteins--deficiency Neoplasm Proteins--metabolism Olmesartan Medoxomil Organic Anion Transporters--metabolism Organic Anion Transporters, Sodium-Independent--metabolism Penicillin G--pharmacology Probenecid--pharmacology Prodrugs--metabolism Protein Binding Protein Isoforms--metabolism Sincalide--metabolism Solute Carrier Organic Anion Transporter Family Member 1B3 Tetrazoles--metabolism Transfection p-Aminohippuric Acid--pharmacology