Removal of cysteinylation from an unpaired sulfhydryl in the variable region of a recombinant monoclonal IgG1 antibody improves homogeneity, stability, and biological activity. [electronic resource]
- Journal of pharmaceutical sciences Feb 2008
- 775-90 p. digital
Publication Type: Journal Article
0022-3549
10.1002/jps.21014 doi
Antibodies, Monoclonal--chemistry Chromatography, Gel Cysteine Drug Stability Immunoglobulin G--chemistry Immunoglobulin Variable Region--chemistry Protein Folding Protein Processing, Post-Translational Recombinant Proteins--chemistry